COLL 215 |
| Doris Nguyen1, Krisanu Bandyopadhyay1, Johannes Tan2, Angelika Niemz1, and Shenda M. Baker2. (1) Bioengineering, Keck Graduate Institute, 535 Watson Drive, Claremont, CA 91711, (2) Department of Chemistry, Harvey Mudd College, 301 12th Street, Claremont, CA 91711 |
| A major goal in nanobiotechnology is to gain control over the spatial distribution and orientation of single protein molecules, a goal that has not been achieved to date in the development of protein nanoarray technologies. We are exploring a novel approach for the oriented immobilization of proteins within arrays of surface nanopores. Proteins are ordered in an oriented fashion by self-assembly on a ligand containing monolayer at the air-water interface. Surface immobilization of discrete proteins in confined surface nanopores is achieved by Langmuir Blodgett deposition of this monolayer onto silicon wafers with etched arrays of surface nanopores. We herein report initial results obtained for the model system streptavidin – biotin, and are in the process of expanding our studies to the generation of oriented single antibody nanoarrays. |
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Posters: Fundamental Research in Surface and Colloid Chemistry
6:00 PM-8:00 PM, Monday, March 29, 2004 Disneyland -- North Exhibit Hall, Poster
Division of Colloid and Surface Chemistry |
