COLL 297 |
| Brandon L Weeks, Biosecurity Support Laboratory, Lawrence Livermore National Laboratory, Chemistry and Materials Science Division, Livermore, CA 94551 and James J. DeYoreo, Chemistry and Materials Science, Lawrence Livermore National Laboratory, 7000 East Ave, L-350, Livermore, CA 94550. |
| Increasing efforts have been put into the developments of cantilever-based micro sensors. These devices show fast responses, high sensitivity, and are suitable for mass production. Currently, they are mainly applied for quality and process control, diagnostic biosensing for medical analysis, fragrance design (“artificial noses”), and gas analysis. The application of single cantilever sensors to determine quantities below the detection limits of equivalent “classical” methods such as thermal, chemical, stress, mass loading or magnetic signals has been demonstrated in the literature. Experimental results will be presented for the detection of specific strains of Salmonella. By coating one side of the cantilever with monoclonal antibodies the cantilevers show specific and selective detection of individual strains. Subsequent SEM imaging of the cantilever after exposure to the pathogen shows the Salmonella only adheres to the side of the cantilever with the antibody and shows detection limits in the range of 25 organisms for detection .
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Bio-Colloids
8:30 AM-10:30 AM, Tuesday, March 30, 2004 Marriott -- Orange County 3, Oral
Division of Colloid and Surface Chemistry |