NUCLWednesday, March 26, 2003

8:00 AM-12:20 PM Convention Center -- Room 390,Oral
Development of High-LET Therapeutic Radiopharmaceuticals
Auger Emitters and At-211
Presidings:M. Jules Mattes
Hans Lundqvist
Organizers:Martin W. Brechbiel
D. Scott Wilbur
8:00 AM Introductory Remarks
8:05 AM 95Preclinical research on Auger therapy
Hans Lundqvist, E. Bohl, J. Carlsson, L. Gedda, V. Tolmachev, A. Orlova, A. Bruskin, S. Sjoberg
8:35 AM 96Comparison of antibodies conjugated to I-125, In-111, Ga-67, or I-131 for single-cell kill
M. Jules Mattes, Martin W. Brechbiel, Rosana B. Michel
9:05 AM 97Photonuclear production of In-111
Herbert A. Moore, Richard F. Testa, Robert C. Block, Nathaniel Bobeck, Yaron Danon
9:25 AM 98Evaluation of astatine-211-labeled targeted radiotherapeutics
Michael R. Zalutsky, Oscar Pozzi, Xiao-Guang Zhao, Kevin L. Alston
9:55 AM Intermission
10:15 AM 99Small astatinated molecules in tumor targeting
Per Hoff
10:45 AM 100Optimizing methods for labeling biomolecules with astatine-211
D. Scott Wilbur, Donald K. Hamlin, Ming-Kuan Chyan, Catherine Foulon, Michael R. Zalutsky, Tim Wedge, M. Frederick Hawthorne
11:05 AM 101N-Succinimidyl 3-[211At]astato-4-guanidinomethylbenzoate: An acylation agent for labeling internalizing antibodies with alpha-particle-emitting 211At
Ganesan Vaidyanathan, Donna J. Affleck, Michael R. Zalutsky
11:25 AM 102Alpha-emitting radioisotopes conjugated to anti-HER2/neu diabodies for the radioimmunotherapy of solid tumors
Gregory P Adams, Calvin Shaller, Kayhan Garmestani, Abohawariat Tesfaye, Thomas A. Waldmann, Martin W. Brechbiel
11:45 AM 103Combined effect of a cytostatic agent and targeted radiotherapy with 211At-EGF: Experimental therapy studies in vitro
Åsa Liljegren Sundberg, Ylva Almquist, Vladimir Tolmachev, Lars Gedda, Anna Orlova, Erik Blomquist, Jorgen Carlsson
12:05 PM Discussion

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The 225th ACS National Meeting, New Orleans, LA, March 23-27, 2003