NUCLTuesday, March 25, 2003

1:30 PM-5:45 PM Convention Center -- Room 390,Oral
Development of High-LET Therapeutic Radiopharmaceuticals
Bismuth-213 Radiopharmaceuticals
Presidings:Joseph G. Jurcic
Barry J. Allen
Organizers:Martin W. Brechbiel
D. Scott Wilbur
1:30 PM 77Alpha-particle immunotherapy with bismuth-213-labeled anti-CD33 monoclonal antibody HuM195 in myeloid leukemia
Joseph G. Jurcic, John M. Burke, Michael R. McDevitt, Chaitanya R. Divgi, George Sgouros, Ronald D. Finn, Steven M. Larson, David A. Scheinberg
2:00 PM 78Alpha radioimmunotherapy of B-lineage non-Hodgkin’s lymphoma using 213Bi-labeled anti-CD19- and anti-CD20-CHX-A"-DTPA conjugates
Steffen Heeger, Gerhard Moldenhauer, Gerlinde Egerer, Horst Wesch, Simona Martin, Tuomo Nikula, Christos Apostolidis, Martin W. Brechbiel, Anthony D. Ho, Rainer Haas
2:30 PM 79In vitro evaluation of 213Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: Relative biological efficacy with respect to apoptosis induction and chromosomal damage by the micronucleus assay
Katia Vandenbulcke, Filip De Vos, Fritz Offner, Jan Philippe, Christos Apostolidis, Roger Molinet, Tuomo K Nikula, Klaus Bacher, Virginie de Gelder, Anne Vral, Christophe Lahorte, Hubert Thierens, Rudi A. Dierckx, Guido Slegers
2:50 PM 80Radioimmunotherapy with bismuth-213 as nonmyeloablative conditioning for marrow transplantation
Wolfgang A. Bethge, D. Scott Wilbur, Donald K. Hamlin, Erlinda B. Santos, Martin W. Brechbiel, Rainer Storb, Brenda M. Sandmaier
3:20 PM Intermission
3:30 PM 81In vitro and preclinical testing of Bi-213-labeled antimelanoma monoclonal antibody 9.2.27
Syed M Abbas Rizvi, Yong Li, Chand Raja, Barry J. Allen
4:00 PM 82Radioimmunotherapy of infections using alpha- and beta-emitting radionuclides
Ekaterina Dadachova, Ruth Bryan, Antonio Nakouzi, Annie Frenkel, Joshua D. Nosanchuk, Andrew D. Schweitzer, Arturo Casadevall
4:30 PM 83Cold and alpha-conjugated anti-CD20 induce different in vitro apoptosis responses in B-chronic lymphocytic leukemia and splenic lymphoma with villous lymphocytes
Katia Vandenbulcke, Fritz Offner, Guido Slegers, Filip De Vos, Virginie de Gelder, Annick Willems, Simona Martin, Roger Molinet, Christos Apostolidis, Tuomo K Nikula, Willem Janssens, Ann Jansenns, Hubert Thierens, Rudi A. Dierckx, Jan Philippe
4:50 PM 84Molecular mechanisms of alpha-particle-induced cytotoxicity in human leukemic cells as revealed by gene-expression profiling
Simona Martin, Ralf Kronenwett, Katia Vandenbulcke, Fritz Offner, Slawomir Kliszewski, Christos Apostolidis, Ramon Carlos, Willem Janssens, Maurice Leroy, Tuomo Nikula, Jan Philippe, Rainer Haas
5:10 PM 85Long-term survival and toxicity in Balb/c mice after systemic administration of alpha emitters
Horst Wesch, Steffen Heeger, Frauke Spiecker, Folker Amelung, Martin W. Brechbiel, Gerhard Moldenhauer, Tuomo Nikula
5:30 PM Discussion

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The 225th ACS National Meeting, New Orleans, LA, March 23-27, 2003