Biological uses of semiconducting nanocrystals

IEC 19

Wolfgang J. Parak1, R Boudreau1, M Le Gros1, Daniele Gerion1, Daniela Zanchet2, Christine M. Micheel1, Shara C. Williams1, Paul Alivisatos2, and C Larabell1. (1) Department of Chemistry, University of California, Berkeley and Lawrence Berkeley National Laboratory, 419 Latimer Hall, Box 101, Berkeley, CA 94720, (2) Department of Chemistry, University of California, Berkeley, 419 Latimer Hall, Box 101, Berkeley, CA 94720
We report the ready incorporation of silica coated quantum dots into a wide variety of eukaryotic cells. The cells can be fluroescently labelled in this manner. The cells continue to divide and remain healthy. In experiments where the quantum dots are deposited on a collagen substrate and then cells are deposited on top of this, the cells incorporate any quantum dots that underlie them. When the cells migrate on a substrate, they injest all the dots they pass over. This provides a convenient and rapid way for assessing cell metastatic potential.