IEC 250 |
| Owen R. T. Thomas1, Timothy J. Hobley1, Andrea Meyer2, and Matthias Franzreb2. (1) BioCentrum-DTU, Centre for Process Biotechnology, Technical University Denmark, Building 223, Lyngby, DK-2800, Denmark, (2) Institute for Technical Chemistry, Forschungszentrum Karlsruhe GmbH, Hermann v. Helmholtz Platz 1, Eggenstein-Leopoldshafen, 76344, Germany |
| Few serious attempts to scale up magnetic particle–based separations for biotechnological use have been made until very recently. This fact is surprising given that magnetic particle–based separations have a long history of use at large scale in the mineral processing industries and have also become popular in biotechnology in the laboratory for the rapid handling of large numbers of small volumes of crude samples. In this presentation we shall discuss the needs of the biotech industry and how we have accommodated these in the design of a robust and scaleable approach to macromolecule purification that we term High Gradient Magnetic Fishing (HGMF). With the aid of selected examples from our laboratories we shall illustrate the future potential and development of HGMF, and highlight its key advantages over the use of traditional and new chromatographic techniques for the large–scale recovery of macromolecular products from large volumes of crude bioprocess liquors. |
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Magnetic-Field-Enhanced Separation and Related Processes (sponsored by Separation Science & Technology Subdivision)
9:00 AM-11:55 AM, Thursday, March 27, 2003 Convention Center -- Room 394, Oral
Division of Industrial and Engineering Chemistry |